Compositions and methods for treating peripheral arterial disease

• Main Authors: THOMPSON DAVID, NITSCHKE YVES, RUETSCH FLORIAN
• Format: Patent
• Language: Chinese; English
• Published: 07.07.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides compositions and methods for treating peripheral arterial disease in a subject by administering an exonucleotide pyrophosphatase phosphodiesterase-1 (ENPP1) agent or an exonucleotide pyrophosphatase phosphodiesterase-3 (ENPP3) agent. 本公开提供了通过施用外核苷酸焦磷酸酯酶磷酸二酯酶-1(ENPP1)药剂或外核苷酸焦磷酸酯酶磷酸二酯酶-3(ENPP3)治疗受试者的外周动脉疾病的组合物和方法。