Thermodynamically unstable substituted cyclohexane compound and synthesis method thereof

• Main Authors: WANG LUJIN, SHI HONGJIN, YIN GUOYIN
• Format: Patent
• Language: Chinese; English
• Published: 07.07.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to the technical field of organic synthesis, in particular to a thermodynamically unstable substituted cyclohexane compound and a synthesis method thereof, and the synthesis method comprises the following steps: in an inert atmosphere, dissolving a metal nickel catalyst, a ligand, alkali and silicon-hydrogen in a dry organic solvent, then adding substituted exocyclic olefin and alkyl halide R2X to obtain a reaction mixture, and reacting for 2-4 hours at room temperature to obtain the substituted cyclohexane compound. And sealing the reaction mixture, reacting, removing the organic solvent after the reaction is completed, and separating and purifying to obtain the target product 1, 2-cis or 1, 3-trans or 1, 4-cis compound. The invention provides an efficient method for preparing a thermodynamically unstable substituted cyclohexane compound through coupling of metal catalyzed exocyclic olefin and alkyl halide. The method is simple and convenient to operate, raw materials are cheap and easy