Debenzoylated paeoniflorin-6 '-O-benzenesulfonate, and preparation method and application of debenzoylated paeoniflorin-6'-O-benzenesulfonate

• Main Authors: MAO YUKANG, HAN YAMING, WANG GUOCAI, YUAN CHENG, XU WENDONG, LIU JUYAN, LI JING, TANG SHUNZHI, CAI HONGFEI, ZHANG ZHEN, ZHANG QIN, CAO LIN
• Format: Patent
• Language: Chinese; English
• Published: 04.07.2023
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention relates to the technical field of medicinal chemistry, in particular to debenzoylpaeoniflorin-6 '-O-benzenesulfonate, a preparation method thereof and application of debenzoylpaeoniflorin-6'-O-benzenesulfonate to treatment of sicca syndrome and rheumatoid arthritis. The preparation method comprises the following steps: taking paeoniflorin-6 '-O-benzene sulfonate as a raw material, hydrolyzing, extracting, carrying out column chromatography, and separating a preparative liquid phase to obtain the paeoniflorin-6'-O-benzene sulfonate. The bioavailability of the debenzoylated paeoniflorin-6 '-O-benzenesulfonate is higher than that of paeoniflorin and paeoniflorin-6'-O-benzenesulfonate, and the debenzoylated paeoniflorin-6 '-O-benzenesulfonate has a remarkable curative effect on sicca syndrome and rheumatoid arthritis and can be prepared into medicines for treating sicca syndrome and rheumatoid arthritis. 本发明涉及药物化学技术领域，具体涉及去苯甲酰芍药苷-6'-O-苯磺酸酯、其制备方法及治疗干燥综合征与类风湿性关节炎的用途。其制备方法在于以芍药苷-6'-O-苯磺酸酯为原料，水解，经萃取、柱层析