Debenzoylated paeoniflorin-6 '-O-benzenesulfonate, and preparation method and application of debenzoylated paeoniflorin-6'-O-benzenesulfonate
The invention relates to the technical field of medicinal chemistry, in particular to debenzoylpaeoniflorin-6 '-O-benzenesulfonate, a preparation method thereof and application of debenzoylpaeoniflorin-6'-O-benzenesulfonate to treatment of sicca syndrome and rheumatoid arthritis. The prepa...
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Main Authors | , , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
04.07.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to the technical field of medicinal chemistry, in particular to debenzoylpaeoniflorin-6 '-O-benzenesulfonate, a preparation method thereof and application of debenzoylpaeoniflorin-6'-O-benzenesulfonate to treatment of sicca syndrome and rheumatoid arthritis. The preparation method comprises the following steps: taking paeoniflorin-6 '-O-benzene sulfonate as a raw material, hydrolyzing, extracting, carrying out column chromatography, and separating a preparative liquid phase to obtain the paeoniflorin-6'-O-benzene sulfonate. The bioavailability of the debenzoylated paeoniflorin-6 '-O-benzenesulfonate is higher than that of paeoniflorin and paeoniflorin-6'-O-benzenesulfonate, and the debenzoylated paeoniflorin-6 '-O-benzenesulfonate has a remarkable curative effect on sicca syndrome and rheumatoid arthritis and can be prepared into medicines for treating sicca syndrome and rheumatoid arthritis.
本发明涉及药物化学技术领域,具体涉及去苯甲酰芍药苷-6'-O-苯磺酸酯、其制备方法及治疗干燥综合征与类风湿性关节炎的用途。其制备方法在于以芍药苷-6'-O-苯磺酸酯为原料,水解,经萃取、柱层析 |
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Bibliography: | Application Number: CN202211709124 |