Preparation method of sucralose

The invention provides a preparation method of sucralose, and belongs to the technical field of fine chemical engineering. The preparation method of sucralose provided by the invention comprises the following steps: mixing cane sugar, N, N-dimethylformamide, trichloroethane and thionyl chloride, and...

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Bibliographic Details
Main Authors CHEN YONGLE, ZHANG HAO, ZHANG ZHENGSONG, GUO SHIYU
Format Patent
LanguageChinese
English
Published 30.06.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention provides a preparation method of sucralose, and belongs to the technical field of fine chemical engineering. The preparation method of sucralose provided by the invention comprises the following steps: mixing cane sugar, N, N-dimethylformamide, trichloroethane and thionyl chloride, and carrying out chlorination reaction to obtain chlorinated product feed liquid; adjusting the pH value of the chlorination product feed liquid to be alkaline, and carrying out decomposition reaction to obtain tetrachlorosucrose; and mixing the tetrachlorosucrose, water and an alkaline hydrolysis agent, and carrying out alkaline hydrolysis reaction to obtain the sucralose. According to the method, the traditional method for protecting hydroxyl on the sixth site of the cane sugar is abandoned, the cane sugar is directly used as a raw material for chlorination, the tetrachlorosucrose is prepared, a chlorine atom group on the sixth site of the tetrachlorosucrose has higher activity compared with other groups, dechlorina
Bibliography:Application Number: CN202280005504