Application of JR14a in preparation of medicine or health care product for treating cerebral apoplexy

The invention discloses an application of JR14a in preparation of a medicine or a health care product for treating cerebral apoplexy. JR14a is used for treating a middle cerebral artery occlusion/reperfusion mouse model constructed by a suture method, and the JR14a is found to be capable of remarkab...

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Bibliographic Details
Main Authors ZHAO JING, TANG JIUTANG, GAN HUI, LUO YUJIA
Format Patent
LanguageChinese
English
Published 30.06.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses an application of JR14a in preparation of a medicine or a health care product for treating cerebral apoplexy. JR14a is used for treating a middle cerebral artery occlusion/reperfusion mouse model constructed by a suture method, and the JR14a is found to be capable of remarkably improving the acute-stage neurological function score of a mouse cerebral ischemia model, reducing the volume of cerebral infarction body (area) and improving the cerebral apoplexy. The traditional Chinese medicine composition is capable of improving cerebral edema degree and blood-brain barrier permeability, promoting improvement of neuromotor function of cerebral ischemia reperfusion model mice in a recovery phase, reducing cerebral infarction body (area) volume, preventing or relieving brain tissue atrophy, and prolonging median lifetime. 本发明公开了一种JR14a在制备治疗脑卒中药物或保健品中的应用，本发明通过将JR14a用于治疗线栓法构建的大脑中动脉闭塞/再灌注小鼠模型，发现JR14a可显著改善小鼠脑缺血模型急性期神经功能评分，减小脑梗死体(面)积，改善脑水肿程度和血脑屏障通透性，促进脑缺血再灌注模型小鼠恢复期神经运动功能改善，减小脑梗死体(面)积，预防或缓解脑组织萎缩，延长
Bibliography:Application Number: CN202211674185