True human antibodies specific for interleukin 1 alpha (IL-1 alpha)

A fully human monoclonal Ab comprises: (i) an antigen binding variable region that exhibits a very high binding affinity for IL-1 [alpha]; and (ii) a constant region which is effective in both activating the complement system by C1q binding and binding to several different Fc receptors. 完全人类单克隆Ab包含：...

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Bibliographic Details
Main Authors KUZ-MICHEVA GALINA, SIMARD JOHN, SHIVASWAMY SUSHMA SHIVASWAMY
Format Patent
LanguageChinese
English
Published 27.06.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:A fully human monoclonal Ab comprises: (i) an antigen binding variable region that exhibits a very high binding affinity for IL-1 [alpha]; and (ii) a constant region which is effective in both activating the complement system by C1q binding and binding to several different Fc receptors. 完全人类单克隆Ab包含：(i)抗原结合可变区，其对IL-1α表现出非常高的结合亲和力；和(ii)恒定区，其在通过C1q结合来活化补体系统和与几种不同的Fc受体结合两方面是有效的。
Bibliography:Application Number: CN202180068595