Triparatide lipoacylated derivative
The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site 16, the site 26, the site 27 and/or the site 33 of the N end of teriparatide. The teriparatide analogue disclosed by the invention has the c...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
27.06.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site 16, the site 26, the site 27 and/or the site 33 of the N end of teriparatide. The teriparatide analogue disclosed by the invention has the capability of transcellular transport mediated by a cholic acid transporter, and the cell infiltration capability and the stability in gastrointestinal digestive enzymes are obviously improved compared with those of teriparatide.
本发明提供一类特立帕肽类似物，所述类似物是在特立帕肽N端的13位、16位、26位、27位和/或33位发生修饰和/或氨基酸替换。本发明的特立帕肽类似物，具有胆酸转运体介导的跨细胞转运的能力，细胞渗透能力及在胃肠道消化酶中的稳定性较特立帕肽有了明显的升高。 |
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| AbstractList | The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site 16, the site 26, the site 27 and/or the site 33 of the N end of teriparatide. The teriparatide analogue disclosed by the invention has the capability of transcellular transport mediated by a cholic acid transporter, and the cell infiltration capability and the stability in gastrointestinal digestive enzymes are obviously improved compared with those of teriparatide.
本发明提供一类特立帕肽类似物，所述类似物是在特立帕肽N端的13位、16位、26位、27位和/或33位发生修饰和/或氨基酸替换。本发明的特立帕肽类似物，具有胆酸转运体介导的跨细胞转运的能力，细胞渗透能力及在胃肠道消化酶中的稳定性较特立帕肽有了明显的升高。 |
| Author | ZHANG XIQUAN DONG YUANZHEN FENG JUN RUAN SIDA LU WEIGEN |
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| DocumentTitleAlternate | 特立帕肽脂酰化衍生物 |
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| RelatedCompanies | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY SHANGHAI DUOMIRUI BIOTECHNOLOGY CO., LTD CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD |
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| Snippet | The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site... |
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| Title | Triparatide lipoacylated derivative |
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