Triparatide lipoacylated derivative

The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site 16, the site 26, the site 27 and/or the site 33 of the N end of teriparatide. The teriparatide analogue disclosed by the invention has the c...

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Bibliographic Details
Main Authors ZHANG XIQUAN, FENG JUN, LU WEIGEN, DONG YUANZHEN, RUAN SIDA
Format Patent
LanguageChinese
English
Published 27.06.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a teriparatide analogue. According to the analogue, modification and/or amino acid substitution are carried out on the site 13, the site 16, the site 26, the site 27 and/or the site 33 of the N end of teriparatide. The teriparatide analogue disclosed by the invention has the capability of transcellular transport mediated by a cholic acid transporter, and the cell infiltration capability and the stability in gastrointestinal digestive enzymes are obviously improved compared with those of teriparatide. 本发明提供一类特立帕肽类似物，所述类似物是在特立帕肽N端的13位、16位、26位、27位和/或33位发生修饰和/或氨基酸替换。本发明的特立帕肽类似物，具有胆酸转运体介导的跨细胞转运的能力，细胞渗透能力及在胃肠道消化酶中的稳定性较特立帕肽有了明显的升高。
Bibliography:Application Number: CN202211615599