Sipunculus nudus polypeptide functionalized iridium oxide nano-enzyme with antibacterial effect as well as preparation method and application of sipunculus nudus polypeptide functionalized iridium oxide nano-enzyme

• Main Authors: ZHU XUFENG, CHEN JINCAN, CHEN JINJUN, CHEN LANMEI, LIANG CHUNMEI, SUN QIANG, CHEN LIANG
• Format: Patent
• Language: Chinese; English
• Published: 27.06.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses sipunculus nudus polypeptide functionalized iridium oxide nano-enzyme with an antibacterial effect as well as a preparation method and application of the sipunculus nudus polypeptide functionalized iridium oxide nano-enzyme, and belongs to the technical field of biological medicines. The iridium oxide nano-enzyme SBI NPs is synthesized, the drug-resistant bacterial infection resistance activity of the iridium oxide nano-enzyme SBI NPs is tested, the efficient MRSA resistance activity of the iridium oxide nano-enzyme SBI NPs is verified through in-vitro antibacterial and anti-biofilm experiments, and it is found that the SBI NPs is superior to vancomycin in the aspect of biofilm resistance. The invention is helpful for interpreting the scientific connotation of the anti-infection effect of the metal oxide nano-enzyme, and is expected to provide a scientific basis for improvement of the curative effect, clinical combined application and even development of bacterial surface adsorptive ac