Compositions and methods for treating allograft angiopathy, smoke disease, smoke disease syndrome, and intimal proliferation

• Main Authors: BANKS DAVID, M. WOZ, NESTOR CHRISTOPHER A, NITSCHKE YVES, RUETSCH FLORIAN, SKORNIK ERIC
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides compositions and methods for treating allograft angiopathy and smog disease (MMD) and smog disease syndrome (MMS), treating, inhibiting, or preventing undesirable intimal proliferation in a subject by administering an exonucleotide pyrophosphatase phosphodiesterase-1 (ENPP1) agent or an exonucleotide pyrophosphatase phosphodiesterase-3 (ENPP3). 本公开提供了用于通过以下来治疗同种异体移植物血管病和烟雾病(MMD)和烟雾病综合征(MMS)，治疗、抑制或预防受试者的不期望的内膜增殖的组合物和方法：施用外核苷酸焦磷酸酶磷酸二酯酶-1(ENPP1)药剂或外核苷酸焦磷酸酶磷酸二酯酶-3(ENPP3)。