Synthesis method for preparing 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]-5-methyl-N-propyl-2-alkynyl-1, 3-thiazole-2-amine

• Main Authors: COSTA CRISTINA MARIE, STEEN SCOTT, PALMER ANDREW, REDDISON JOEL
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure relates to the field of chemistry and medicine, and more particularly to a process for the preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]-5-methyl-N-propyl-2-alkynyl-1, 3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts and crystalline forms thereof, as well as methods for the preparation of 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ethyl]-5-methyl-N-propyl-2-alkynyl-1, 3-thiazol-2-amine (Compound 1). Methods for the treatment of congenital adrenal hyperplasia (CAH). 本公开内容涉及化学和医药领域，更具体地涉及制备4-(2-氯-4-甲氧基-5-甲基苯基)-N-[(1S)-2-环丙基-1-(3-氟-4-甲基苯基)乙基]-5-甲基-N-丙-2-炔基-1,3-噻唑-2-胺(化合物1)、其药学上可接受的盐和晶型的方法，用于治疗先天性肾上腺皮质增生症(CAH)的方法。