Blood concentration detection method based on two-dimensional ultra-high performance liquid chromatography and mass spectrometry

• Main Authors: JIA AO, ZHAO YIDAN, MA YONGCHENG, PAN LULU, WANG AIFENG
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a plasma concentration detection method based on two-dimensional ultra-high performance liquid chromatography and mass spectrometry, and belongs to the technical field of plasma detection methods, and the method comprises the steps of plasma concentration detection of special use grade antibacterial drugs, pathogenic bacteria quantity detection and evaluation of the effect of the special use grade antibacterial drugs. According to the method, the blood concentration of the special-use-level antibacterial drug in the blood sample of the patient is obtained through a two-dimensional ultra-high performance liquid chromatography and mass spectrometry analysis technology; a comprehensive evaluation system is formed by combining the number of pathogenic bacteria detected by a blood specimen pathogenic bacteria detection technology, the dosage of the injected special use-level medicine, the time from initial medicine injection and the number of times of medicine injection; through evaluation