Endometrial receptivity marker in unknown-cause recurrent embryo planting failure disease

• Main Authors: SU HUAPENG, XIA WENJUAN, LI JINCHENG, HUANG BOXIAN, LU JIAFENG, HUANG PENG
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides an application of a KIAA1429 gene or protein as a biomarker in preparation of a reagent for evaluating endometrial receptivity of a subject, wherein the subject is an in vitro fertilization-embryo transplantation patient or further an unknown recurrent embryo implantation failure (RIF) patient. The expression level of the KIAA1429 of the in vitro fertilization-embryo transplantation patient in the endometrium can be conveniently and quickly detected, the endometrium receptivity state can be reflected, and a new basis and means are provided for evaluating whether the patient is suitable for embryo transplantation or not. 本发明提供了KIAA1429基因或蛋白作为生物标志物在制备用于受试者子宫内膜容受性评估试剂中的用途，所述受试者为体外受精-胚胎移植患者或进一步为不明原因反复胚胎种植失败(RIF)患者。方便快捷的检测体外受精-胚胎移植患者KIAA1429在子宫内膜中的表达水平，将能反映子宫内膜容受性状态，为评估患者是否适合进行胚胎移植提供新的依据和手段。