Application of Cu/ETS-10 catalyst in catalytic synthesis of 3-methylene isoindoline-1-ketone and derivatives thereof

• Main Authors: HU HUILING, TANG TIANDI, ZHU CHAOJIE, LIU CHANGJUN, LI ZHUOFEI, FU WENQIAN
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to the field of heterogeneous catalysis organic synthesis, and discloses an application of a Cu/ETS-10 catalyst in catalytic synthesis of 3-methylene isoindoline-1-ketone and a derivative thereof. The Cu/ETS-10 catalyst is prepared by adopting an equivalent-volume impregnation method, and the method comprises the following specific steps: sequentially adding 2-iodobenzamide, phenylacetylene and a zeolite catalyst into a reaction tube, adding a reaction solvent dimethyl sulfoxide (DMSO) under N2 atmosphere, putting into a heater at 100-120 DEG C, reacting for 2-12 hours, after the reaction is finished, centrifuging, filtering, collecting supernate, and concentrating under reduced pressure to obtain the Cu/ETS-10 catalyst. And performing column chromatography separation and purification on the crude product to obtain the 3-methylene isoindoline-1-ketone, wherein the yield can reach 98%. Compared with the prior art, the method has the advantages that soluble metal salt, ligand and other add