Medicine for improving endothelial index of coronary microcirculation dysfunction and identification method thereof

• Main Authors: LIANG CHENYUAN, ZHAO HUI, JIANG HONGYING, YANG DA, JIANG RUIJIA, CHENG GONG, WANG YIYANG
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of biological medicine, and discloses a medicine for improving coronary microcirculation dysfunction endothelial indexes and an identification method of the medicine, and the coronary microcirculation dysfunction endothelial indexes comprise adropin, irisin, ESM-1, GDF-15 and ARG; the identification method of the medicine for improving the endothelial index of the coronary microcirculation dysfunction comprises the following steps: respectively detecting the levels of adropin, irisin, ESM-1, GDF-15 and ARG; measuring and calculating MBF in resting and load states by using SPECT, and obtaining CFR; and statistical analysis of the data is carried out by adopting SPSS26.0 software. By analyzing the level change of adropin, irisin, ESM-1, GDF-15 and ARG in serum when the Gelan Xinning soft capsule is combined with conventional western medicines to treat CMD patients, effective targets for the Gelan Xinning soft capsule to generate effects are explored, and reference is