Application of N-acetylglucosamine in prevention and treatment of MPTP-induced neuron injury

• Main Authors: LIU CHANGFENG, LIU FENG, YUAN TAO, DONG HONGJING, WANG XIAO, LU JIANXING, DUAN WENJUAN, LI GUILING, LYU RUIMIN, JI WENHUA
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicines, and particularly relates to application of N-acetylglucosamine in prevention and treatment of MPTP-induced neuron injury. The N-acetylglucosamine is wide in source and low in cost, new application of the N-acetylglucosamine is found, clinical application of the N-acetylglucosamine is increased, and a new application field is developed. It is found for the first time that N-acetylglucosamine has a good protection effect and a strong effect on MPTP-induced dopaminergic neuron damage, is expected to have a good effect on prevention and treatment of Parkinson's disease, and has a good medicinal prospect. 本发明属于医药领域，具体涉及N-乙酰氨基葡萄糖在防治MPTP诱导神经元损伤中的应用。N-乙酰氨基葡萄糖来源广泛，成本低廉，本发明发现了N-乙酰氨基葡萄糖的新用途，增加了N-乙酰氨基葡萄糖的临床适用症，开拓了一个新的应用领域。本发明首次发现N-乙酰氨基葡萄糖对MPTP诱导的多巴胺能神经元损伤的保护效果好，作用强，预期对于防治帕金森病也具有良好效果，具有良好的药用前景。