Method for preparing imidazo [1, 2-a] pyrrolo [2, 3-e] pyrazine compound and solid-state form thereof

• Main Authors: ALLIAN AYMAN D, OTHMAN AHMED A, BORCHARDT THOMAS B, NORDSTROEM FREDRIK LARS, BHAGAVATULA LAKSHMINARAYANA, MOHAMED MOHAMED-ESLAM F, COLLENDER BRIAN, MAYER PETER T, GAYENS JOHN, MULHERN MATHEW M, MARROUM PATRICK J, SHEIKH AHMAD Y, ROZEMA MICHAEL J
• Format: Patent
• Language: Chinese; English
• Published: 23.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a process for the preparation of (3S, 4R)-3-ethyl-4-(3H-imidazo [1, 2-A] pyrrolo [2, 3-E] pyrazin-8-yl)-N-(2, 2, 2-trifluoroethyl) pyrrolidine-1-carboxamide and solid state forms thereof. The present disclosure relates to methods for the preparation of (3S, 4R)-3-ethyl-4-(3H-imidazo [1, 2-a] pyrrolo [2, 3-e] pyrazin-8-yl)-N-(2, 2, 2-trifluoroethyl) pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment, including the treatment of rheumatoid arthritis, kits, methods of synthesis, and products characterized by the methods. 本发明涉及制备(3S，4R)-3-乙基-4-(3H-咪唑并[1，2-A]吡咯并[2，3-E]吡嗪-8-基)-N-(2，2，2-三氟乙基)吡咯烷-1-甲酰胺及其固态形式的方法。本披露涉及用于制备(3S，4R)-3-乙基-4-(3H-咪唑并[1，2-a]吡咯并[2，3-e]吡嗪-8-基)-N-(2，2，2-三氟乙基)吡咯烷-1-甲酰胺、其固态形式、和相应的药物组合物的方法、治疗(包括治疗类风湿性关节炎)的方法、试剂盒、合成方法、以及由方法表征的产品(products-by-process)。