Preparation method and application of abacavir impurity A

• Main Authors: LU YUNXIA, TIAN LEI, WANG ZHIBANG, BAI JUN, LIAO JIEHAI, WANG ZHE, PENG JIEWEI, CHENG JUN
• Format: Patent
• Language: Chinese; English
• Published: 09.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; TESTING

The invention discloses a preparation method and application of abacavir impurity A. The preparation method specifically comprises the following steps: taking a compound 1 and a compound 2 as starting raw materials, generating a compound 3 under an alkaline condition, then generating a compound 4 under an acidic condition from the compound 3, and reacting the compound 4 with ammonia water to generate the impurity A, a new thought is provided for synthesis of the abacavir impurity A, the initial raw materials of the synthesis method are easy to obtain, the reaction conditions of the synthesis route are mild, the reaction operation is safe, the yield and the purity are good, the preparation requirements of the impurity can be met, and the abacavir impurity A synthesis method has important significance on research of abacavir impurities. 本发明公开了一种阿巴卡韦杂质A的制备方法及用途，具体以化合物1和化合物2为起始原料，在碱性条件下生成化合物3，接着化合物3在酸性条件下生成化合物4，化合物4与氨水反应生成杂质A；本发明为阿巴卡韦杂质A的合成提供了新思路，合成方法起始原料易得，合成路线反应条件温和、反应操作安全，且收率和纯度较好能够满足对该杂质的制备需求，对阿巴卡韦杂质的研究具有重要意义