Novel kinase inhibitor with dimethyl isoindolone structure as well as preparation method and application of novel kinase inhibitor

• Main Authors: DING JIAN, LIU BO, SONG ZILAN, AI JING, XIE CHENGHU, ZHANG AO, GENG MEIYU
• Format: Patent
• Language: Chinese; English
• Published: 06.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a novel kinase inhibitor with a dimethyl isoindolone structure as well as a preparation method and application of the novel kinase inhibitor. Specifically, the compound disclosed by the invention has a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses a preparation method of the compound and application of the compound in prevention and/or treatment of HPK1 related diseases. 本发明涉及一类具有二甲基异吲哚酮结构的新型激酶抑制剂及其制备方法和用途。具体地，本发明化合物具有式I所示结构，其中各基团和取代基的定义如说明书中所述；本发明还公开了所述化合物的制备方法及其在预防和/或治疗HPK1相关疾病方面的用途。