Preparation method of N-methyl-1, 2, 5, 6-methyl tetrahydronicotinate

The invention discloses a preparation method of N-methyl-1, 2, 5, 6-methyl tetrahydronicotinate, which comprises the following steps: preparing methyl nicotinate, preparing ammonium salt of brominated methyl nicotinate, and preparing arecoline. The preparation process of arecoline is greatly optimiz...

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Bibliographic Details
Main Authors YING YANQING, PAN WENJUN, QIAN HAISHU, XU HAIBIN
Format Patent
LanguageChinese
English
Published 06.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method of N-methyl-1, 2, 5, 6-methyl tetrahydronicotinate, which comprises the following steps: preparing methyl nicotinate, preparing ammonium salt of brominated methyl nicotinate, and preparing arecoline. The preparation process of arecoline is greatly optimized, cheap 3-cyanopyridine is used as an initial raw material, methyl nicotinate is obtained through direct hydrogen chloride alcoholysis, operation is easy and convenient, the yield of methyl nicotinate is obviously increased, the amount of waste water is greatly reduced, and the method is suitable for industrial production. Methylation is carried out by using bromomethane instead of iodomethane to obtain brominated methyl nicotinate ammonium salt, then reduction is carried out by using a sodium borohydride, acetic acid and ethanol system, and salification is carried out with a hydrobromic acid aqueous solution according to a ratio of 1: 1 after distillation, so that the process is safe and stable, the operation is
Bibliography:Application Number: CN202310221215