Method for continuously synthesizing 4-methoxypropiophenone

The invention discloses a method for continuously synthesizing 4-methoxypropiophenone, which comprises the following steps: uniformly pre-mixing anisole, propionic anhydride and an acylation catalyst to form a homogeneous system, continuously pumping the homogeneous system into a tubular reactor for...

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Bibliographic Details
Main Authors WU QINGDIAN, WANG JIAN, LIU XIAOTAO
Format Patent
LanguageChinese
English
Published 06.06.2023
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Summary:The invention discloses a method for continuously synthesizing 4-methoxypropiophenone, which comprises the following steps: uniformly pre-mixing anisole, propionic anhydride and an acylation catalyst to form a homogeneous system, continuously pumping the homogeneous system into a tubular reactor for staying reaction, and after the staying reaction, enabling a reaction solution to flow out from a discharge port to obtain 4-methoxypropiophenone. And carrying out reduced pressure rectification on the reaction liquid to obtain the 4-methoxypropiophenone. According to the invention, the catalyst, the dosage of the catalyst, the reaction temperature and the reaction pressure are selected, so that the reaction efficiency is greatly improved, the continuous reaction is facilitated, and the continuous production of the anethole intermediate is realized through the simple tubular reactor. The tubular reactor is adopted for reaction, the tubular reactor has the advantages of being small in size, large in specific surfac
Bibliography:Application Number: CN202211507838