Enterococcus durans strain with anti-inflammatory characteristic, culture method and application

• Main Authors: WU YUJIANG, AWANG COGGI, LEI YU, WANG XIAOLONG, BA GUI, SOLANDARD, DE JI, RENQING COM, ZHANG KE
• Format: Patent
• Language: Chinese; English
• Published: 02.06.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The invention belongs to the technical field of microorganisms, and in particular relates to enterococcus durans 98D with an anti-inflammatory characteristic as well as a culture method and application of the enterococcus durans 98D. The collection number of the enterococcus durans is CCTCC NO: M 20221217, and the enterococcus durans can recover intestinal inflammation induced by DSS and escherichia coli, improve the integrity of colon epithelial barrier, reduce the expression levels of pro-inflammatory genes TNF-alpha, IL-6 and IL-1beta and improve the expression levels of anti-inflammatory genes IL-10 and tight junction protein genes ZO-1, Occludin and Claudin-1, has a treatment effect on the intestinal inflammation, and can be used for treating the intestinal inflammation. And anti-inflammatory products such as anti-inflammatory drugs, anti-inflammatory health-care products or anti-inflammatory feed additives can be prepared. 本发明属于微生物技术领域，具体涉及一株具有抗炎特性的耐久肠球菌(Enterococcus durans)98D、培养方法及应用。所述耐久肠球菌的保藏编号为CCTC