Synthesis of glycoside compound

The invention discloses synthesis of a glycoside compound (5-[(2R, 3R, 4R, 5R, 6R)-3-acetamido-4, 5-diacetoxy-6-acetoxymethyl-2-tetrahydropyranyloxy] valeric acid), which comprises the following two steps: step 1, in an inert atmosphere and a first reaction solvent, a compound 1 and a compound 2 gen...

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Bibliographic Details
Main Authors LI BAOHUA, MIAO XIUYAN, ZHOU LILI, ZHANG ZHILIU, SUN PENGDA, CHEN DEAN
Format Patent
LanguageChinese
English
Published 30.05.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The invention discloses synthesis of a glycoside compound (5-[(2R, 3R, 4R, 5R, 6R)-3-acetamido-4, 5-diacetoxy-6-acetoxymethyl-2-tetrahydropyranyloxy] valeric acid), which comprises the following two steps: step 1, in an inert atmosphere and a first reaction solvent, a compound 1 and a compound 2 generate a compound 3 under the action of a catalyst 1 and an auxiliary agent; and 2, in an inert atmosphere and a second reaction solvent, generating 5-[(2R, 3R, 4R, 5R, 6R)-3-acetamido-4, 5-diacetoxy-6-acetoxymethyl-2-tetrahydropyranyloxy] valeric acid from the compound 3 under the action of an oxidant and a catalyst 2, thereby obtaining the 5-[(2R, 3R, 4R, 5R, 6R)-3-acetamido-4, 5-diacetoxy-6-acetoxymethyl-2-tetrahydropyranyloxy] valeric acid. The synthesis reaction conditions are mild and safe, the reaction process is easy to control, the operation is simple and convenient, the synthesis route is short, the raw materials are cheap and easy to obtain, and the industrial production application of the 5-[(2R, 3R, 4R,
Bibliography:Application Number: CN202211673760