Preparation method of 2-(4-aminophenyl) butyric acid

• Main Authors: SHENG LI, ZHANG LIHUA, LI XINGYE, ZHANG FENGQIN
• Format: Patent
• Language: Chinese; English
• Published: 23.05.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention provides a preparation method of 2-(4-aminophenyl) butyric acid, and relates to the field of chemical pharmaceuticals, the preparation method is characterized in that 2-(4-nitrophenyl) butyric acid is used as a reaction raw material, formate is used as a hydrogen source, and a metal catalyst and a protonic solvent are used for reaction to prepare the 2-(4-aminophenyl) butyric acid. The method has the advantages of simple operation, no use of toxic reagents, no need of special reaction equipment, small catalyst usage amount, high reaction conversion rate and good product quality. The preparation method and the obtained 2-(4-aminophenyl) butyric acid can be used for preparing indobufen. 本发明提供了一种2-(4-氨基苯基)丁酸的制备方法，涉及化学制药领域，该制备方法以2-(4-硝基苯基)丁酸为反应原料，以甲酸盐为氢源、使用金属催化剂和质子性溶剂进行反应制备2-(4-氨基苯基)丁酸。本发明的方法操作简单，不使用毒性试剂、不需要特殊反应设备、催化剂使用量少，反应转化率高，产品质量好，该制备方法以及所得到的2-(4-氨基苯基)丁酸可用于吲哚布芬的制备。