Treatment of cancer

• Main Author: TRIEBEL FREDERIC
• Format: Patent
• Language: Chinese; English
• Published: 16.05.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to the use of a LAG-3 protein or a derivative thereof and optionally a chemotherapeutic agent in the treatment of cancer in a subject. The subject has one or more of the following: having a low monocyte count, suffering from Luminal type B breast cancer, age less than about 85 years old, having been previously treated with a CDK4/6 inhibitor, and having not been previously treated with taxane chemotherapy. Suitably, the cancer is breast cancer, such as hormone receptor positive breast cancer. 本发明涉及LAG-3蛋白或其衍生物和任选的化疗剂在治疗受试者的癌症中的用途。该受试者具有以下项中的一项或多项：具有低单核细胞计数、患有Luminal B型乳腺癌、年龄小于约85岁、先前已用CDK4/6抑制剂治疗和先前未接受过紫杉烷化疗的治疗。合适地，该癌症是乳腺癌，诸如激素受体阳性乳腺癌。