Solid aza-fused ring amide compound and application thereof

• Main Authors: WANG JIE, WANG YETING, GONG DENGHUANG, MI GUORUI, MA ERQIAN, FAN LIXUE, MA YUXIU
• Format: Patent
• Language: Chinese; English
• Published: 16.05.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a solid compound shown in a formula (A), a crystalline compound shown in the formula (A), a specific crystal form of the compound, a pharmaceutical composition containing the compound and application of the pharmaceutical composition, the crystalline compound shown in the formula (A) and the specific crystal form of the compound have good crystallinity and stability, and in-vivo and in-vitro drug effects show that the compound can be used for preparing a pharmaceutical preparation. The compound shown in the formula (A) has a good inhibition effect on wild and mutant kinases, cells and in-vivo tumors, and has good patent medicine potential. 本发明提供了一种固体形式的式(A)所示化合物、结晶形式的式(A)所示化合物、其具体晶型、包含其的药物组合物及其用途，结晶形式的式(A)所示化合物及其具体晶型具有良好的结晶度和稳定性，体内外药效显示，式(A)所示化合物对野生型和突变型激酶、细胞及体内肿瘤均具有良好的抑制效果，具有良好的成药潜力。