Pyrimidine compound containing hydroxamic acid fragment as well as preparation method and application of pyrimidine compound

The invention discloses a pyrimidine compound containing a hydroxamic acid fragment as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method of the pyrimidine compound containing the hydroxamic acid fragment comprises the follow...

Full description

Saved in:
Bibliographic Details
Main Authors YAN LONGJIA, LONG ZHIWU, ZUO YAQING, LE YI, LIU LI
Format Patent
LanguageChinese
English
Published 16.05.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention discloses a pyrimidine compound containing a hydroxamic acid fragment as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method of the pyrimidine compound containing the hydroxamic acid fragment comprises the following steps: (1) mixing a substituted 2, 4-dichloropyrimidine compound with an aminothiophene methyl ester compound, and carrying out nucleophilic substitution reaction to obtain a compound A; (2) mixing the compound A with different substituted aniline compounds in an acidic environment, and carrying out nucleophilic substitution reaction to obtain a compound B; and (3) mixing the compound B with hydroxylamine hydrochloride in an alkaline environment, and carrying out nucleophilic substitution reaction to obtain the pyrimidine compound containing the hydroxamic acid fragment. The pyrimidine compound containing the hydroxamic acid fragment is novel in structure, has good water solubility and has good application pros
Bibliography:Application Number: CN202310144039