Solid preparation containing clopidogrel and preparation method

• Main Authors: HAN DAE-JIN, XU XUEFEI, WANG XIAOMING, DONG JINHU, XIE LIMIN, WANG JIPEI
• Format: Patent
• Language: Chinese; English
• Published: 16.05.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention belongs to the field of medicine, and particularly relates to a clopidogrel solid preparation and a preparation method thereof.The clopidogrel solid preparation is composed of a tablet core and a coating layer, and the tablet core comprises clopidogrel, an antioxidant, a surfactant, a filler, an adhesive and a disintegrating agent; auxiliary materials of the coating layer comprise a methacrylic acid-methyl methacrylate copolymer and/or a methacrylic acid-ethyl acrylate copolymer, the preparation is prepared through a fluidized bed, and the product is simple in preparation process and adapts to clinical requirements on clopidogrel. 本发明属于医药领域，具体涉及一种氯吡格雷固体制剂及其制备方法，所述的氯吡格雷固体制剂由片芯和包衣层组成，片芯包含氯吡格雷、抗氧化剂、表面活性剂、填充剂、粘合剂、崩解剂，包衣层辅料包含甲基丙烯酸-甲基丙烯酸甲酯共聚物和/或甲基丙烯酸-丙烯酸乙酯共聚物，所述制剂经流化床制备而成，产品制备工艺简单，适应临床对于氯吡格雷的需求。