Method for exploring influence of TRPV1 on lipid metabolism of type 2 diabetes
The invention discloses a method for exploring the influence of TRPV1 on lipid metabolism of type 2 diabetes mellitus, which comprises the following steps of: firstly, collecting data and samples, namely collecting demographic data, clinical biochemical index results and blood samples of type 2 diab...
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Main Authors | , , , , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
12.05.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The invention discloses a method for exploring the influence of TRPV1 on lipid metabolism of type 2 diabetes mellitus, which comprises the following steps of: firstly, collecting data and samples, namely collecting demographic data, clinical biochemical index results and blood samples of type 2 diabetes mellitus patients and healthy control people; according to the invention, a mouse with diabetes mellitus type 2 is cultured, a mouse model with diabetes mellitus type 2 is constructed, glucose tolerance (OGTT) and insulin resistance (ITT) are fed, histopathologic changes of the mouse are detected and recorded, and a TRPV1 agonist and an inhibitor are injected into the abdominal cavity of the mouse with diabetes mellitus. A corresponding metabolic pathway of TRPV1 channel protein participating in regulation and control of fat metabolism of type 2 diabetes mellitus is detected, so that the regulation and control action mechanism of TRPV1 on fat metabolism of type 2 diabetes mellitus is determined, a scientific b |
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Bibliography: | Application Number: CN202310038113 |