Monoclonal antibody targeting human IGSF9 and application thereof

• Main Authors: LI ZUNLING, WANG HONGYING, SHAO SHUHONG, ZHANG JUAN, LIU YIFAN, ZHAO ZHILING
• Format: Patent
• Language: Chinese; English
• Published: 09.05.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a monoclonal antibody targeting human IGSF9 and application of the monoclonal antibody, and belongs to the technical field of monoclonal antibodies. According to the monoclonal antibody targeting the human IGSF9, the amino acid sequence of a heavy chain of the monoclonal antibody targeting the human IGSF9 is shown as SEQ ID NO.1, and the amino acid sequence of a light chain of the monoclonal antibody targeting the human IGSF9 is shown as SEQ ID NO.2. According to the monoclonal antibody targeting the human IGSF9, the inhibiting effect of the IGSF9 protein on T cells is blocked and the activity of the T cells is recovered by recognizing the IGSF9 protein mediating proliferation inhibition of the T cells, so that the growth of tumor cells is inhibited; after being combined with other immunosuppressive molecule drugs, the compound has an obvious synergistic effect, and a new direction is provided for tumor treatment. 本发明提供了一种靶向人IGSF9的单克隆抗体及其应用，属于单克隆抗体技术领域。本发明提供的靶向人IGSF9的单克隆抗体，所述靶向人IGSF9的单克