Preparation method of composite gel particles based on aqueous two-phase emulsion

• Main Authors: WANG XINHE, SONG XIMING, MENG QINGBO, YOU YUANXIANG, YU XIBO
• Format: Patent
• Language: Chinese; English
• Published: 05.05.2023
• Subjects: ADHESIVES; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DYES; GENERAL PROCESSES OF COMPOUNDING; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC MACROMOLECULAR COMPOUNDS; PAINTS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; POLISHES; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING; WORKING-UP

The invention particularly relates to a preparation method of composite gel particles based on an aqueous two-phase emulsion, which comprises the following steps: carrying out Schiff base reaction on mPEG-CHO and glucose oxidase according to the mass ratio of 1: 1 to synthesize an aqueous two-phase emulsion emulsifier; adding an aqueous two-phase emulsion emulsifier into a mixed solution of a PEG (Polyethylene Glycol) aqueous solution and a Dex aqueous solution to form an aqueous two-phase emulsion; and adding a sodium alginate aqueous solution into the aqueous two-phase emulsion, and carrying out gelation reaction in a calcium chloride aqueous solution to form the composite gel particles based on the aqueous two-phase emulsion. According to the invention, a simple gelation strategy is adopted, the aqueous two-phase emulsion is fixed in the gel particles, and the aqueous two-phase emulsion is fixed in the gel particles due to the three-dimensional network structure of the hydrogel, so that demulsification of