Antibacterial peptide ATMP7 mutant with improved antibacterial activity and application thereof

• Main Authors: XIAO ZHIZHUANG, FU WUBING, XU RUIXIAN, YU WENJUN, SUN JIANFEI, FANG ANRAN, WANG BO
• Format: Patent
• Language: Chinese; English
• Published: 05.05.2023
• Subjects: CHEMISTRY; FODDER; FOODS OR FOODSTUFFS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The invention discloses an antibacterial peptide ATMP7 mutant with improved antibacterial activity and application of the antibacterial peptide ATMP7 mutant. On the basis of an amino acid sequence of a natural antibacterial peptide ATMP7, antibacterial peptide mutants A7-M1, A7-M2, A7-M3, A7-M4, A7-M5, A7-M6 and A7-M7 with remarkably improved antibacterial activity are obtained in a manner of combining amino acid site-saturated mutation and random mutation. The antibacterial peptide ATMP7 mutant provided by the invention is convenient to artificially synthesize and low in cost, the bactericidal effect on gram-positive bacteria is remarkably superior to that of the antibacterial peptide ATMP7, the stress resistance is better, the heat resistance is better, and the antibacterial peptide ATMP7 mutant can remarkably reduce the feed conversion ratio of bred animals and improve the growth performance index of the bred animals in livestock and poultry and aquatic animal breeding and has a good application prospect.