Difunctional sound-sensitive agent as well as preparation method and application thereof

• Main Authors: MA SUFANG, BIAN JIANHONG, ZHAO HUANHUAN, LIU YULONG, LI XIANG, YU QIANG
• Format: Patent
• Language: Chinese; English
• Published: 05.05.2023
• Subjects: CHEMISTRY; ELECTROTHERAPY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; RADIATION THERAPY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; ULTRASOUND THERAPY

The invention discloses a difunctional sound-sensitive agent as well as a preparation method and application thereof, and belongs to the technical field of chemical and biological materials. Aiming at the problem of single function of the existing sound-sensitive agent for tumor treatment, the invention constructs the difunctional sound-sensitive agent for sonodynamic and gas therapy. The sonosensitizer can release active oxygen (ROS) and nitric oxide (NO) at the same time under ultrasonic (US) stimulation, and has the potential of gas and sonodynamic synergistic treatment. The difunctional sonosensitizer has the advantages of being simple in synthesis process, good in biocompatibility, high in ultrasonic responsiveness and the like, and has important significance on promoting sonodynamic and gas synergistic treatment and achieving clinical application. 本发明公开了一种双功能声敏剂及制备方法和应用，属于化学生物材料技术领域。针对目前用于肿瘤治疗的声敏剂功能单一的问题，本发明构建可用于声动力和气体治疗的双功能声敏剂。该声敏剂在超声(US)刺激下，可同时释放活性氧(ROS)和一氧化氮(NO)，具有气体和声动力协同治疗的潜力。该双功能声敏剂具有合成过程简单、生物相容性好