Enteric-coated enrofloxacin granules and preparation method thereof

• Main Authors: JIANG LIHUI, CHEN WEIDONG, CHEN JIAN, LIN HUI, ZHU LINGXIANG
• Format: Patent
• Language: Chinese; English
• Published: 05.05.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of A61K9 of IPC classification, in particular to enrofloxacin enteric-coated granules and a preparation method thereof. The enrofloxacin enteric-coated granule comprises an enrofloxacin granule core and a coating film wrapping the surface of the enrofloxacin granule core, the average particle size of the enrofloxacin enteric-coated particles is 30-100 meshes. According to the enrofloxacin enteric-coated granules prepared by the invention, gastrointestinal absorption is generally not influenced by gastric emptying, the drug release reproducibility is relatively high, the distribution area of the drug on the surface of the gastrointestinal tract is increased, the bioavailability of the drug is improved, and local stimulation is reduced; after use, the higher the blood concentration is, the better the clinical effect is, the enteric preparation is prepared, the medicine is intensively released and absorbed in the intestinal tract, the blood concentration can be obviously improv