Crystal gel adsorption chromatography separation method of lactic acid

• Main Authors: ZHANG SONGHONG, LI XIAOBIN, YUN JUNXIAN, LOU XIAOLING
• Format: Patent
• Language: Chinese; English
• Published: 02.05.2023
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING

The invention discloses a cryogel adsorption chromatography separation method of lactic acid, which comprises the following steps: polymerizing hydroxyethyl methylacrylate as a monomer to form a cryogel matrix skeleton, chemically modifying to obtain a cryogel medium, diluting a solution containing lactic acid with deionized water to obtain a loading solution, washing the cryogel medium with deionized water, and drying to obtain the cryogel adsorption chromatography separation method of lactic acid. And washing off unadsorbed impurities, eluting with a 0.1-3 M salt solution, and collecting to obtain an eluent containing lactic acid. The method for separating lactic acid is simple in process, easy to amplify, low in energy consumption and free of secondary pollution, the cryogel medium can be reused, and the method is expected to be widely applied to the lactic acid separation and purification process. 本发明公开了一种乳酸的晶胶吸附层析分离方法，所述的方法以甲基丙烯酸羟乙酯为单体进行聚合而成的晶胶基质骨架，经化学修饰后得到晶胶介质，用去离子水稀释含有乳酸的溶液得到上样液，用去离子水冲洗晶胶介质，洗去未被吸附的杂质，用