Protein structure prediction method and device, equipment and storage medium

• Main Authors: HE WENJUN, QIAO NAN, JIANG HUALIANG, TIAN QI, ZHANG LEI, XIE LINGXI, HE JIANZHONG, LIU DENGHUI, WANG DINGYAN, CHENG XI, LIN XINYUAN, ZHANG XIAOPENG, XU ZHIMENG, ZHENG MINGYUE, XU CHI
• Format: Patent
• Language: Chinese; English
• Published: 28.04.2023
• Subjects: INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

The embodiment of the invention provides a protein structure prediction method and device, equipment and a storage medium. The method comprises the following steps: for a to-be-predicted protein, obtaining a plurality of multi-sequence comparison results based on an amino acid sequence of the protein, then obtaining a plurality of pieces of structure information in one-to-one correspondence with the plurality of multi-sequence comparison results by utilizing a protein structure prediction model, and selecting the structure information meeting a target condition from the plurality of pieces of structure information. Wherein the multi-sequence comparison result indicates a plurality of homologous amino acid sequences of the amino acid sequence, and due to the fact that the space structures of the proteins corresponding to the two homologous amino acid sequences are often close, the space structures of the proteins can be accurately predicted according to the multi-sequence comparison result. Besides, according