Drug delivery system based on biologically active compound functionalized calcium phosphate nanoparticles from Euphorbia pekinensis extract and uses thereof

• Main Authors: MELCHIZO ALONSO CARLOS, RAMIREZ RODRIGUEZ GUSTAVO BALAZS, DELGADO LOPEZ JOSE MANUEL, MESSAS HERNANDEZ CARLOS, GALLISTER MOYA MIRANDA, BERMUDEZ PEREZ FERNANDO, ORTIZ CUEZADA RODRIGO, MARTINEZ RAUL, MURILLO CANCHO ANDRES FRANCISCO, GASSIS ROBLES VERONICA, PRADOS SALAZAR JUAN CARLOS, CABEZA MONTILLA LUIS, LOPEZ-JURADO ROMEO DE LA CRUZ MANUEL, POERSFORKY JASON M
• Format: Patent
• Language: Chinese; English
• Published: 21.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a composition comprising biologically active molecules esculetin and euphorbidin, which have antineoplastic activity and thus can be used for the treatment and/or prevention of cancer, in particular colorectal cancer, pancreatic cancer and glioblastoma. Furthermore, the present invention relates to a drug delivery system consisting of calcium phosphate nanoparticles functionalized with said bioactive molecules, preferably obtained from an extract of Euphorbia pekinensis. The invention also relates to a plant-derived ethanol extract obtained from the degreased powder of mature euphorbia pekinensis seeds. 本发明涉及一种包含生物活性分子七叶内酯和大戟素的组合物，它们具有抗肿瘤活性，因此可用于治疗和/或预防癌症，特别是结直肠癌、胰腺癌和胶质母细胞瘤。此外，本发明涉及由用所述生物活性分子官能化的磷酸钙纳米颗粒组成的药物递送系统，优选从大戟提取物中获得。本发明还涉及从大戟成熟种子的脱脂粉中获得植物来源的乙醇提取物。