Silica-based fluorescent nanoparticles

• Main Authors: BRADBURY MICHELLE, WIESNER ULRICH, PENATE MEDINA OLLA, BURNS ANDREW, LARSON STEVEN, OW HOOSWENG, LEWIS JASON
• Format: Patent
• Language: Chinese; English
• Published: 21.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The present invention provides silica-based fluorescent nanoparticles that can be used to accurately detect, characterize, monitor and treat diseases such as cancer. The diameter of the nanoparticles ranges from about 0.1 nm to about 100 nm. The nanoparticles have a fluorescent compound located therein, and have higher brightness and fluorescent quantum yield than free fluorescent compounds. The nanoparticles may be coated with an organic polymer, such as polyethylene glycol (PEG). The nanoparticles may further be conjugated with ligands capable of binding to cellular components associated with a particular cell type. A therapeutic agent may be linked to the nanoparticles. In order to make the nanoparticles detectable not only by optical fluorescence imaging but also by other imaging techniques, radionuclides/radio metals or paramagnetic ions may be conjugated to the nanoparticles. 本发明提供了可以用于准确检测、表征、监测和治疗诸如癌症的疾病的基于二氧化硅的荧光纳米颗粒。所述纳米颗粒的直径的范围为约0.1nm至约100nm。所述纳米颗粒具有位于其内的荧光化合物，并且具有比游离荧光化合物高的亮度和荧光量子产率。所述纳米颗粒可以涂布有有机聚