Application of mycobacterium tuberculosis Ag85BDNA vaccine in preparation of preparation for regulating intestinal function of mouse

• Main Authors: WAN QIAOFENG, LI HUI, YAO SI, YANG YUXIN, ZHANG WEI
• Format: Patent
• Language: Chinese; English
• Published: 18.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention relates to the technical field of vaccine application, and particularly discloses application of a mycobacterium tuberculosis Ag85B DNA vaccine in preparation of a preparation for regulating intestinal functions of mice. According to the invention, the mycobacterium tuberculosis Ag85BDNA vaccine stimulates intestinal mucosa to generate SIgA antibodies, the relative richness of the phylum of thick-walled bacteria is also increased, the relative richness of the phylum of bacteroides is reduced, and the richness of lactobacillus reuteri and lactobacillus johnsonii is increased. 本发明涉及疫苗应用技术领域，具体公开了结核分枝杆菌Ag85B DNA疫苗在制备调节小鼠肠道功能制剂中的应用。本发明中结核分枝杆菌Ag85BDNA疫苗刺激肠粘膜产生SIgA抗体，还增加了厚壁菌门的相对丰富度，降低拟杆菌门的相对丰富度，增加了罗伊氏乳杆菌和约氏乳杆菌的丰富度。