Corynebacterium glutamicum for high yield of L-serine and method for improving production of L-serine

• Main Authors: YE JINFANG, SHI JINGSONG, LIU ANQIAN, ZHANG XIAOMEI, XU ZHENGHONG
• Format: Patent
• Language: Chinese; English
• Published: 14.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates to Corynebacterium glutamicum capable of realizing high yield of L-serine and a method for improving production of L-serine, the strain is named Corynebacterium glutamicum A36-pDser, and is preserved in China General Microbiological Culture Collection Center on January 11, 2018, the preservation address is No. 3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.15172. The invention further discloses a preparation method of the Corynebacterium glutamicum. The yield of the L-serine produced by the corynebacterium glutamicum reaches 33.7 g/L and is increased by 10.86% compared with that of an original strain, and after the alpha-ketoglutaric acid is added, the biomass is not greatly changed, the yield of the L-serine is increased by 36.2%, and the efficiency of producing the L-serine by using the corynebacterium glutamicum is greatly improved. 本发明涉及一种高产L-丝氨酸的谷氨酸棒杆菌及提高L-丝氨酸生产的方法，该菌株命名为谷氨酸棒杆菌(Corynebacterium glutamicum)A36-pDser，于2018年01月11日保藏于