Tetrahydroisoindolone compound as well as preparation method and application thereof

• Main Authors: YANG DONGDONG, WU WENFU, ZHOU HAIBO, SUN PINGHUA, LIU JUN, WANG DONG, FANG RENJIE, XU JUN, CHEN QIUXIAN, XIAO HAICHUAN, ZHANG QIANG
• Format: Patent
• Language: Chinese; English
• Published: 14.04.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of medicines, and discloses tetrahydroisoindolone compounds as shown in a formula I and application of antibacterial drugs of the tetrahydroisoindolone compounds. In-vivo and in-vitro pharmacodynamic verification shows that most of the tetrahydroisoindolone compounds have excellent antibacterial activity, can be used for preparing antibacterial inhibitors, and have a certain antibacterial effect. 本发明涉及医药领域，发明了一类式I所示的四氢异吲哚酮类化合物及其抗菌药物的应用。本发明所涉及的四氢异吲哚酮类化合物经体内外药效验证，所得化合物大都具有优秀的抑菌活性，可用于制备抗菌抑制剂，具有一定抗菌效果。