Fc-CD80 FUSION PROTEINS AND CONJUGATES THEREOF AND USES THEREOF

• Main Authors: SONG LINGYUN, HONG WEIDONG, HE YUN, HU PINLIANG, YANG WENDI, ZOU JING
• Format: Patent
• Language: Chinese; English
• Published: 07.04.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an Fc-CD80 fusion protein. The Fc-CD80 fusion protein is a fusion protein formed by connecting a CD80 extracellular domain (ECD) to a C end of an Fc structural domain of immunoglobulin. The Fc-CD80 fusion protein can be used to prepare a conjugate comprising the Fc-CD80 fusion protein as a first component and comprising a second component comprising a second effector molecule, the second component being located at the N-terminus of the first component. The invention also provides a conjugate of the Fc-CD80 fusion protein, a pharmaceutical composition comprising the Fc-CD80 fusion protein and/or conjugate, and the use of the Fc-CD80 fusion protein, conjugate or pharmaceutical composition for the treatment or prevention of cancerous diseases in an individual. 本发明提供了Fc-CD80融合蛋白，其是在免疫球蛋白Fc结构域的C端连接有CD80胞外结构域(ECD)的融合蛋白。所述Fc-CD80融合蛋白能够用于制备缀合物，所述缀合物包含所述Fc-CD80融合蛋白作为第一组分、且包含含有第二效应分子的第二组分，所述第二组分位于第一组分的N端。本发明还提供了Fc-CD80融合蛋白的缀合物，包含所述Fc-CD80融合蛋白和/或缀合物的药物组合物，以及所述Fc-CD80融合蛋白、缀合物或药物组合物用于在个体中治疗或预防癌性疾病的用