Superficial esophageal squamous carcinoma serum exosome miRNAs expression profile, detection kit and application

• Main Authors: YAO XIANGYI, FENG YADONG, ZHANG YOUYU, SHI RUIHUA
• Format: Patent
• Language: Chinese; English
• Published: 07.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention discloses a superficial esophageal squamous carcinoma serum exosome miRNAs expression profile, a detection kit and application of the superficial esophageal squamous carcinoma serum exosome miRNAs. The expression profile is mainly composed of hsa-miR-30a-5p and hsa-miR-99a-5p which are expressed in an up-regulation mode, and hsa-miR-185-5p, hsa-miR-7-5p and hsa-miR-96-5p which are expressed in a down-regulation mode. The invention discloses a serum exosome miRNAs expression profile of a superficial esophageal squamous cell carcinoma patient, a differential expression miRNAs molecular map between the superficial esophageal squamous cell carcinoma patient and healthy people is defined, and a biological marker for early diagnosis, prognosis evaluation and curative effect prediction of the superficial esophageal squamous cell carcinoma disease is screened from the molecular map. A superficial esophageal squamous carcinoma cell characteristic miRNAs molecular expression map is analyzed; the correlati