Pravastatin sodium tablet and preparation method thereof

• Main Authors: HAN ZHIWEI, GAO WEIHONG, WANG KUN, LIANG FENGLIN, ZHANG XINXIN, LI YANPU, MIAO XIAOGE
• Format: Patent
• Language: Chinese; English
• Published: 07.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a pravastatin sodium tablet and a preparation method thereof. The pravastatin sodium tablet is prepared from the following raw materials in parts by weight: 100 parts of pravastatin sodium, 0.5 to 1 part of antioxidant, 40 to 100 parts of magnesium oxide, 1300 to 1600 parts of filler, 60 to 100 parts of disintegrating agent, 20 to 30 parts of lubricant and 400 to 600 parts of adhesive. By adding the oxidizing agent, limiting the particle size D90 of magnesium oxide and adopting the preparation process of combining dry powder granulation and boiling granulation, the variety and content of related substances in the prepared pravastatin sodium tablet are effectively reduced, the content and content uniformity of main medicine components are improved, and the quality of the pravastatin sodium tablet product is improved. 本发明涉及药物制剂技术领域，具体公开一种普伐他汀钠片剂及其制备方法。普伐他汀钠片剂包括如下原料：普伐他汀钠100份，抗氧化剂0.5份-1份，氧化镁40份-100份，填充剂1300份-1