Method for preparing gadadotec acid meglumine by using high-purity tetraracetam (DOTA) and application of gadadotec acid meglumine in preparation of injectable gallon preparation

• Main Authors: MONTIEL LEGAY VINCENT, MARTIN MARTIN FEDERICO RODOLFO, GARCIA SALADO ISABEL, GARCIA RAMOS ARTURO, GARCIA GARCIA VIRGILE, REGUEIRA GOMEZ MIGUEL ANGEL, CHICHARRO MARTIN ROBERTO, SAAS FERNANDES ALFONSO, ALONSO SILVA ISABEL, ECOPOSITO RODRIGUEZ ENRIQUE, VALERO VALERO DAVID, CERECEDA PEREZ JOSE ANTONIO, GALUD MARTINEZ FRANCISCO
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to a method for preparing gadadotec acid meglumine by using high-purity tetraracetam (DOTA), which does not need to use an organic solvent and can optimize the conditions of a synthesis process. The synthesis process for preparing gadadotec acid meglumine by using tetraracetam comprises a purification step of at least performing electrodialysis once. Tetraracetam and gadadotec acid meglumine with the minimum impurity content can be prepared through the steps. 本发明涉及一种利用高纯度四西坦(DOTA)制取钆特酸葡甲胺的方法，该方法无需使用有机溶剂，并且可优化合成工艺的条件。该利用四西坦制取钆特酸葡甲胺的合成工艺包括至少进行一次电渗析的纯化步骤。该步骤可以制取杂质含量最少的四西坦和钆特酸葡甲胺。