Targeted contrast agents for amyloid deposition mri

• Main Authors: ANANPURAGODA ANANTH V, HAGANDHA KETANKUMAR B, TANIFOM ERIC A
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides a liposome composition ("ADx-001"), the ADx-001 comprising: a first phospholipid; a sterically hindered mass excipient capable of stabilizing the liposome composition; a second phospholipid derived with the first polymer; a macrocyclic gadolinium-based imaging agent; and a third phospholipid derived with a second polymer, the second polymer coupled to a targeting ligand. The macrocyclic gadolinium-based imaging agent may be coupled to a fourth phospholipid. 本发明提供一种脂质体组合物("ADx-001")，ADx-001包含：第一磷脂；能够稳定脂质体组合物的位阻大体积赋形剂；利用第一聚合物衍生的第二磷脂；基于大环钆的显像剂；以及利用第二聚合物衍生的第三磷脂，所述第二聚合物偶联着靶向配体。所述基于大环钆的显像剂可以与第四磷脂偶联。