Customune: network tool for designing personalized and group-targeted peptide vaccines

• Main Authors: SAVARINO ANDREA, EL HEFNAWI MAHMOUD, SHITAY IYAT LUCA, MOHAMMED. TAREQ, SOBY DIAZ RICARDO
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Calculation prediction of immunogenic epitopes is a promising platform for designing therapeutic and prophylactic vaccines. For example, a potential target is human immunodeficiency virus (HIV-1), despite several decades of efforts, there is no available vaccines. In fact, due to the huge variability of the virus, a single formulation may not be effective against all or most HIV strains. In addition, upon infection of a host cell, HIV-1 can be integrated into a host genome and form a persistent latent library that is insensitive to common antiretroviral treatments. Thus, a therapeutic vaccine intended to eliminate infected cells may represent a key component of the strategy intended to cure the infection. We introduce an automated algorithm to produce personalized and population-based vaccines. 免疫原性表位的计算预测是设计治疗性和预防性疫苗的一个有前景的平台。例如，一个潜在的目标是人类免疫缺陷病毒(HIV-1)，尽管经过几十年的努力，仍没有可用的疫苗。事实上，由于病毒的巨大可变性，单一配方可能无法有效对抗所有或大多数HIV毒株。此外，在感染宿主细胞后，HIV-1可整合到宿主基因组中并形成对常用抗逆转录病毒治疗不敏感的持久潜伏库。因此，旨在消除感染细胞的治疗性疫苗可能代表了旨在治愈感染的策略的关键组成部分。我们在此引入一种自