Methods and compositions for treating muscular dystrophy

• Main Authors: CARR JOSEPH, BROWN DANIEL, KEEFE DENNIS
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure provides methods of treating a muscular dystrophy (MD), such as Duchenne muscular dystrophy (DMD) or Becker's muscular dystrophy (BMD), in a mammalian subject. The methods are particularly useful in treating, inhibiting, reducing, ameliorating hypertrophic cardiomyopathy, dilated cardiomyopathy, heart failure, and/or myocardial fibrosis, or delaying the onset thereof, in a subject diagnosed with MD and/or being treated with MD. In one embodiment, the method comprises administering to a subject an effective amount of a peptide, such as H-D-Arg-2, 6-Dmt-Lys-PHe-NH2 (also referred to as elamipretide), or a pharmaceutically acceptable salt, hydrate, solvate, and/or tautomer thereof, such as H-D-Arg-2, 6-Dmt-Lys-PHe-NH2, or a pharmaceutically acceptable salt, hydrate, solvate, and/or tautomer thereof, the peptide is optionally combined with at least one other active ingredient (i.e., a drug), such as a corticosteroid, an ACE inhibitor, an ARB, a beta-blocker or a drug that increases or corre