Application of TRIM21 gene detection in tumor diagnosis, treatment selection and prognosis evaluation

• Main Authors: YU YIZHI, YIN SHULEI, CUI LIKUN, XU SHENG
• Format: Patent
• Language: Chinese; English
• Published: 04.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The invention provides application of three-motif E3 ubiquitin ligase 21 (TRIM21) gene detection in tumor diagnosis, treatment selection and prognosis evaluation. Specifically, the invention provides application of the TRIM21 molecule as a biomarker in preparation of a product for immunotyping diagnosis, therapeutic regimen selection and/or prognosis evaluation of melanoma by detecting the TRIM21 level in a sample obtained from a subject, and a corresponding product and method. 提供了三基序E3泛素连接酶21(TRIM21)基因检测在肿瘤诊断、治疗选择和预后评估中的应用。具体提供了TRIM21分子作为生物标志物在制备通过检测获自对象的样品中TRIM21水平来进行黑色素瘤免疫分型诊断、治疗方案选择和/或预后评估的产品中的用途、以及相应的产品和方法。